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Article

HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.

The Journal of biological chemistry - 26 Dec 2008

Durkin Sarah S, Guo Xin, Fryrear Kimberly A, Mihaylova Valia T, Gupta Saurabh K, Belgnaoui S Mehdi, Haoudi Abdelali, Kupfer Gary M, Semmes O John

Abstract excerpt

Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control and cellular response to DNA damage. We showed previously that Tax sequesters huChk2 within chromatin and impairs the response to ionizing radiation. Here we demonstrate that DNA-dependent protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18957425
DOI: 10.1074/jbc.M804931200
PMCID: PMC2605996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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