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Article

Dosage requirement and allelic expression of PAX6 during lens placode formation.

Development (Cambridge, England) - 1 Dec 2000

van Raamsdonk C D, Tilghman S M

Abstract excerpt

Pax6 is a member of the mammalian Pax transcription factor family. Many of the Pax genes display semi-dominant loss-of-function heterozygous phenotypes, yet the underlying cause for this dosage requirement is not known. Mice heterozygous for Pax6 mutations exhibit small eyes (Sey) and in embryos the most obvious defect is a small lens. We have studied lens development in Pax6(Sey)(-1Neu)/+ embryos to understand...

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Source

Identifiers

PMID: 11076764
DOI: 10.1242/dev.127.24.5439

Genes

PAX6
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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