Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis.

PloS one - 1 Jan 2011

Mort Richard L, Bentley Adam J, Martin Francis L, Collinson J Martin, Douvaras Panagiotis, Hill Robert E, Morley Steven D, Fullwood Nigel J, West John D

Abstract excerpt

BACKGROUND: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial stem cell (LESC) deficiency. Heterozygous Pax6(+/Sey-Neu) (Pax6⁺/⁻) mice recapitulate the human disease and are a good model of ARK. Corneal pathologies also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Corneal Stroma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium, Corneal

Share to Intercellular Junctions

Share to Microvilli

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 22220198
DOI: 10.1371/journal.pone.0028895
PMCID: PMC3248408

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis.PMID 22220198Read ↗

PAX6 dosage effects on corneal development, growth, and wound healing.Semantic proximity Read ↗

Effects of elevated Pax6 expression and genetic background on mouse eye development.Semantic proximity Read ↗

Control of Patterns of Corneal Innervation by Pax6Semantic proximity Read ↗

A human-like model of aniridia-associated keratopathy for mechanistic and therapeutic studies.Semantic proximity Read ↗

Normal X-inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice--a model of human filamin A (FLNA) diseases.Semantic proximity Read ↗

Corneal epithelial stem cells: deficiency and regulation.Semantic proximity Read ↗

Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and DiseaseSemantic proximity Read ↗

Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.Semantic proximity Read ↗

Genetic dissection of Pax6 dosage requirements in the developing mouse eye.Semantic proximity Read ↗

Rare corneal clones in mice suggest an age-related decrease of stem cell activity and support the limbal epithelial stem cell hypothesis.Semantic proximity Read ↗

WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesisSemantic proximity Read ↗

Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.