Article
Perspective on RET proto-oncogene and thyroid cancer.
Cancer journal (Sudbury, Mass.) - 1 Jan 2000
Le H N, Norton J A
Abstract excerpt
Much is yet to be learned about cancer and its genetic basis. The discovery of the RET proto-oncogene and its role in tumorigenesis have improved our understanding of thyroid cancer. It is clear that RET is responsible for MEN 2A, MEN 2B, FMTC, and PTC. Although the physical and genetic map of the RET proto-oncogene has been elucidated, the precise mechanism of neoplastic transformation and how it affects...
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