Article
Rapid genotyping by MALDI-monitored nuclease selection from probe libraries.
Nature biotechnology - 1 Nov 2000
Stoerker J, Mayo J D, Tetzlaff C N, Sarracino D A, Schwope I, Richert C
Abstract excerpt
Data on five single-nucleotide polymorphisms (SNPs) per gene are estimated to allow association of disease risks or pharmacogenetic parameters with individual genes. Efficient technologies for rapidly detecting SNPs will therefore facilitate the mining of genomic information. Known methods for SNP analysis include restriction-fragment-length polymorphism polymerase chain reaction (PCR), allele-specific oligomer...
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