Article
RNaseCut: a MALDI mass spectrometry-based method for SNP discovery.
Nucleic acids research - 1 Apr 2003
Krebs Stefan, Medugorac Ivica, Seichter Doris, Förster Martin
Abstract excerpt
MALDI mass spectrometry is an established platform for high-throughput genotyping of single nucleotide polymorphisms (SNPs). For many species and also for specific ethnic groups, the number of described SNPs is far from sufficient. Here we present a method for SNP discovery that can use existing MALDI genotyping platforms and is automation-compatible. The method is based on in vitro RNA transcripts from PCR...
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