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Article

Direct genetic analysis by matrix-assisted laser desorption/ionization mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 1999

Griffin T J, Hall J G, Prudent J R, Smith L M

Abstract excerpt

An approach to analyzing single-nucleotide polymorphisms (SNPs) found in the human genome has been developed that couples a recently developed invasive cleavage assay for nucleic acids with detection by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The invasive cleavage assay is a signal amplification method that enables the analysis of SNPs by MALDI-TOF MS directly...

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Source

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Identifiers

PMID: 10339582
DOI: 10.1073/pnas.96.11.6301
PMCID: PMC26876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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