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Article

Acidic mammalian chitinase is not a critical target for allergic airway disease.

American journal of respiratory cell and molecular biology - 1 Jan 2012

Fitz Lori J, DeClercq Charlene, Brooks Jonathan, Kuang Wen, Bates Brian, Demers Delia, Winkler Aaron, Nocka Karl, Jiao Aiping, Greco Rita M, Mason Lawrence E, Fleming Margaret, Quazi Amira, Wright Jill, Goldman Samuel, Hubeau Cedric, Williams Cara M M

Abstract excerpt

The expression of acidic mammalian chitinase (AMCase) is associated with Th2-driven respiratory disorders. To investigate the potentially pathological role of AMCase in allergic airway disease (AAD), we sensitized and challenged mice with ovalbumin or a combination of house dust mite (HDM) plus cockroach allergen. These mice were treated or not treated with small molecule inhibitors of AMCase, which significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21836154
DOI: 10.1165/rcmb.2011-0095OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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