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Article

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

11 Jan 2002

Abstract excerpt

Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined...

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PMID: 11786643
DOI: 10.1126/science.1065544

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