Article
Negative feedback regulation of Met-dependent invasive growth by Notch.
Molecular and cellular biology - 1 May 2005
Stella M Cristina, Trusolino Livio, Pennacchietti Selma, Comoglio Paolo M
Abstract excerpt
The hepatocyte growth factor (HGF) receptor encoded by the Met oncogene controls a genetic program-known as "invasive growth"-responsible for several developmental processes and involved in cancer invasion and metastasis. This program functions through several regulatory gene products, as yet largely unknown, both upstream and downstream of Met. Here we show that activation of the Notch receptor results in...
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