Article
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Cell - 1 Nov 1996
Maina F, Casagranda F, Audero E, Simeone A, Comoglio P M, Klein R, Ponzetto C
Abstract excerpt
Hepatocyte growth factor (HGF) and its receptor, the Met tyrosine kinase, are determinants of placenta, liver, and muscle development. Here, we show that Met function in vivo requires signaling via two carboxy-terminal tyrosines. Mutation of both residues in the mouse genome caused embryonal deat...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Binding Sites
- DNA, Complementary
- GRB2 Adaptor Protein
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Hepatocyte Growth Factor
- Humans
- Liver
- Macromolecular Substances
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Morphogenesis
- Muscle Fibers, Skeletal
- Muscle, Skeletal