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Article

Linkage disequilibrium mapping in populations of variable size using the decay of haplotype sharing and a stepwise-mutation model.

Genetic epidemiology - 1 Jan 2000

Zhang S, Zhao H

Abstract excerpt

Linkage-disequilibrium (LD) mapping is a powerful tool for fine-mapping disease genes. Recently, McPeek and Strahs [(1999) Am J Hum Genet 65:858-875] proposed a multilocus model for LD mapping based on the decay of haplotype sharing. Here we extend their approach in two ways. First, instead of assuming each marker allele has an equal chance to mutate to one of the other marker alleles, we use the...

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PMID: 11055377
DOI: 10.1002/1098-2272(2000)19:1+<::AID-GEPI15>3.0.CO;2-1

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