Impact of demographic distribution and population growth rate on haplotypic diversity linked to a disease gene and their consequences for the estimation of recombination rate: example of a French Canadian population.

Abstract excerpt

A disease gene introduced into a rapidly growing population by a single individual remains in strong linkage disequilibrium with the surrounding molecular markers. Mapping strategies taking advantage of this phenomenon allow increased mapping resolution as compared to pedigree analysis. Demograph...

Topics

• Confidence Intervals
• Demography
• Female
• Genetic Predisposition to Disease
• Genetics, Population
• Haplotypes
• Humans
• Hypophosphatemia, Familial
• Likelihood Functions
• Linkage Disequilibrium
• Male
• Models, Genetic
• Models, Statistical
• Poisson Distribution
• Quebec