Article
Clonality of pituitary tumours: more complicated than initially envisaged?
Brain pathology (Zurich, Switzerland) - 1 Jul 2001
Clayton R N, Farrell W E
Abstract excerpt
The application of allelotype microsatellite polymorphisms and X chromosome inactivation analysis in samples from women allow assessment of clonality. Early studies showed that sporadic human pituitary tumors are benign adenomas of monoclonal origin. This implies that they arise from de novo somatic mutation(s) within a single pituitary cell. However, the evidence obtained from a number of studies indicate that...
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