Article
No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
Oncogene - 1 May 1992
Warren W, Eeles R A, Ponder B A, Easton D F, Averill D, Ponder M A, Anderson K, Evans A M, DeMars R, Love R
Abstract excerpt
Recent studies have demonstrated that families with the Li-Fraumeni syndrome carry inherited point mutations of the p53 gene. In the present study 25 families with strong histories of breast cancer were screened for the presence of such mutations. Polymerase chain reaction products of exons 5-9 of the p53 gene were examined by single-stranded conformational polymorphism analysis and, in addition, exon 7 was...
Topics
- Breast Neoplasms
- Exons
- Female
- Genes, p53
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction