Article
Absence of germline mutations of exons 5 to 8 of the P53 gene in 26 breast cancer families from the north of France.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1993
Preudhomme C, Fenaux P, Peyrat J P, Fournier J, Bonneterre J, Vennin P
Abstract excerpt
We looked for germline mutations of exons 5 to 8 of the P53 gene in 27 female patients from 26 families originating from the north of France who had breast cancer and at least one first degree relative also affected with breast cancer. Detection of the mutations was made by single strand conforma...
Topics
- Adult
- Aged
- Base Sequence
- Breast Neoplasms
- DNA, Neoplasm
- Exons
- Family
- Female
- France
- Genes, p53
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction