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Article

The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.

Development (Cambridge, England) - 1 Nov 2000

Brouns M R, Matheson S F, Hu K Q, Delalle I, Caviness V S, Silver J, Bronson R T, Settleman J

Abstract excerpt

Rho GTPases direct actin rearrangements in response to a variety of extracellular signals. P190 RhoGAP (GTPase activating protein) is a potent Rho regulator that mediates integrin-dependent adhesion signaling in cultured cells. We have determined that p190 RhoGAP is specifically expressed at high levels throughout the developing nervous system. Mice lacking functional p190 RhoGAP exhibit several defects in neural...

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Identifiers

PMID: 11044403
DOI: 10.1242/dev.127.22.4891

Genes

MARCKS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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