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Article

Molecular correlates of influenza A H5N1 virus pathogenesis in mice.

Journal of virology - 1 Nov 2000

Katz J M, Lu X, Tumpey T M, Smith C B, Shaw M W, Subbarao K

Abstract excerpt

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these...

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Identifiers

PMID: 11044127
DOI: 10.1128/jvi.74.22.10807-10810.2000
PMCID: PMC110957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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