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Article

Rapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouse.

Scientific reports - 17 Jan 2017

Choi Won-Suk, Baek Yun Hee, Kwon Jin Jung, Jeong Ju Hwan, Park Su-Jin, Kim Young-Il, Yoon Sun-Woo, Hwang Jungwon, Kim Myung Hee, Kim Chul-Joong, Webby Richard J, Choi Young Ki, Song Min-Suk

Abstract excerpt

Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in Asia and its spread to Europe and North America has caused great concern for human health. Although the H5N8 virus has been only moderately pathogenic to mammalian hosts, virulence can still increase. We evaluated the pathogenic potential of several H5N8 strains via the mouse-adaptation method. Two H5N8 viruses were sequentially passaged in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28094780
DOI: 10.1038/srep40667
PMCID: PMC5240553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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