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Article

Adaptive Mutations That Occurred during Circulation in Humans of H1N1 Influenza Virus in the 2009 Pandemic Enhance Virulence in Mice.

Journal of virology - 1 Jul 2015

Otte A, Sauter M, Daxer M A, McHardy A C, Klingel K, Gabriel G

Abstract excerpt

UNLABELLED: During the 2009 H1N1 influenza pandemic, infection attack rates were particularly high among young individuals who suffered from pneumonia with occasional death. Moreover, previously reported determinants of mammalian adaptation and pathogenicity were not present in 2009 pandemic H1N1 influenza A viruses. Thus, it was proposed that unknown viral factors might have contributed to disease severity in...

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Identifiers

PMID: 25948752
DOI: 10.1128/JVI.00665-15
PMCID: PMC4473582

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