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Article

A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Jackson David, Hossain Md Jaber, Hickman Danielle, Perez Daniel R, Lamb Robert A

Abstract excerpt

The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to defeat the cellular innate immune response. Recent large-scale genome sequence analysis of avian influenza virus isolates indicated that four C-terminal residues of the NS1 protein is a PDZ ligand domain of the X-S/T-X-V type and it was speculated that it may...

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Identifiers

PMID: 18334632
DOI: 10.1073/pnas.0800482105
PMCID: PMC2393797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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