Article
Effects of rat Axin domains on axis formation in Xenopus embryos.
Development, growth & differentiation - 1 Oct 2000
Fukui A, Kishida S, Kikuchi A, Asashima M
Abstract excerpt
Wnt signaling plays an important role in axis formation in early vertebrate development. Axin is one Wnt signaling regulator that inhibits this pathway. The effects of the injection of mRNA of several rat Axin (rAxin) mutants on axis formation in Xenopus embryos were examined. It was found that rAxin mutants containing only a regulation of G-protein signaling (RGS) domain fragment or with deletion of the RGS...
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