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Article

RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development.

Development (Cambridge, England) - 1 Jul 2000

Wu C, Zeng Q, Blumer K J, Muslin A J

Abstract excerpt

RGS family members are GTPase activating proteins (GAPs) that antagonize signaling by heterotrimeric G proteins. Injection of Xenopus embryos with RNA encoding rat RGS4 (rRGS4), a GAP for G(i) and G(q), resulted in shortened trunks and decreased skeletal muscle. This phenotype is nearly identical to the effect of injection of either frzb or dominant negative Xwnt-8. Injection of human RGS2, which selectively...

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Source

Identifiers

PMID: 10851124
DOI: 10.1242/dev.127.13.2773

Genes

RGS4
RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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