Article
Post-transcriptional regulation of the gli1 oncogene by the expression of alternative 5' untranslated regions.
The Journal of biological chemistry - 12 Jan 2001
Wang X Q, Rothnagel J A
Abstract excerpt
The oncogene GLI1 is involved in the formation of basal cell carcinoma and other tumor types as a result of the aberrant signaling of the Sonic hedgehog-Patched pathway. In this study, we have identified alternative GLI1 transcripts that differ in their 5' untranslated regions (UTRs) and are generated by exon skipping. These are denoted alpha-UTR, beta-UTR, and gamma-UTR according to the number of noncoding exons...
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