Article
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation.
The Journal of biological chemistry - 15 Feb 2002
Yoon Joon Won, Kita Yasuhiro, Frank Daniel J, Majewski Rebecca R, Konicek Beth A, Nobrega Marcelo A, Jacob Howard, Walterhouse David, Iannaccone Philip
Abstract excerpt
The zinc finger transcription factor GLI1, which mediates Sonic hedgehog signaling during development, is expressed in several human cancers, including basal cell carcinoma, medulloblastoma, and sarcomas. We identified 147 genes whose levels of expression were significantly altered in RNA obtained from cells demonstrating a transformed phenotype with stable GLI1 expression or stable Ha-ras expression. Comparison...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.