Article
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.
Human molecular genetics - 1 Aug 2005
Roessler Erich, Ermilov Alexandre N, Grange Dorothy Katherine, Wang Aiqin, Grachtchouk Marina, Dlugosz Andrzej A, Muenke Maximilian
Abstract excerpt
Zinc finger-containing Gli proteins mediate responsiveness to Hedgehog (Hh) signaling, with Gli2 acting as the major transcriptional activator in this pathway in mice. The discovery of disease-associated mutations points to a critical role for GLI2 in human Hh signaling as well. Here, we show that human GLI2 contains previously undescribed 5' sequence, extending the amino-terminus an additional 328 amino acids....
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