Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms.

The Journal of biological chemistry - 15 Oct 2010

Gong Qiuming, Stump Matthew R, Dunn A Russell, Deng Vivianne, Zhou Zhengfeng

Abstract excerpt

The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel. Several hERG1 isoforms with different N- and C-terminal ends have been identified. The hERG1a, hERG1b, and hERG1-3.1 isoforms contain the full-length C terminus, whereas the hERG1(USO) isoforms, hERG1a(USO) and hERG1b(USO), lack most of the C-terminal domain and contain a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to ERG1 Potassium Channel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ether-A-Go-Go Potassium Channels

Share to Patch-Clamp Techniques

Share to Polyadenylation

Share to Protein Isoforms

Share to RNA Precursors

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 20693282
DOI: 10.1074/jbc.M109.095695
PMCID: PMC2952224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms.PMID 20693282Read ↗

A K+ Channel Splice Variant Common in Human Heart Lacks a C-terminal Domain Required for Expression of Rapidly Activating Delayed Rectifier CurrentSemantic proximity Read ↗

Expression and functional characterization of the human ether-à-go-go-related gene (HERG) K+ channel cardiac splice variant in Xenopus laevis oocytes.Semantic proximity Read ↗

The length of the expressed 3’ UTR is an intermediate molecular phenotype linking genetic variants to complex diseasesSemantic proximity Read ↗

Systematic identification of functional SNPs interrupting 3’ UTR polyadenylation signalsSemantic proximity Read ↗

Genomic structure, transcriptional control, and tissue distribution of<i>HERG1</i>and<i>KCNQ1</i>genesSemantic proximity Read ↗

AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon.Semantic proximity Read ↗

Single nucleotide polymorphisms can create alternative polyadenylation signals and affect gene expression through loss of microRNA-regulation.Semantic proximity Read ↗

5′ UTR length regulates alternative N-terminal protein isoform production in health and diseaseSemantic proximity Read ↗

5' UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease.Semantic proximity Read ↗

Identification of a Posttranslational Mechanism for the Regulation of hERG1 K+ Channel Expression and hERG1 Current Density in Tumor CellsSemantic proximity Read ↗

Implications of Poly(A) Tail Processing in Repeat Expansion DiseasesSemantic proximity Read ↗

Gene expression dysregulated of Long Chain Non-coding RNA in patients with idiopathic achalasia: New Insight into PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.