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Article

Dual degradation signals control Gli protein stability and tumor formation.

Genes & development - 1 Feb 2006

Huntzicker Erik G, Estay Ivette S, Zhen Hanson, Lokteva Ludmila A, Jackson Peter K, Oro Anthony E

Abstract excerpt

Regulated protein destruction controls many key cellular processes with aberrant regulation increasingly found during carcinogenesis. Gli proteins mediate the transcriptional effects of the Sonic hedgehog pathway, which is implicated in up to 25% of human tumors. Here we show that Gli is rapidly destroyed by the proteasome and that mouse basal cell carcinoma induction correlates with Gli protein accumulation. We...

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Identifiers

PMID: 16421275
DOI: 10.1101/gad.1380906
PMCID: PMC1361699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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