Article
Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis.
Development, growth & differentiation - 1 Sept 2007
Yoshikane Nami, Nakamura Nao, Ueda Ryu, Ueno Naoto, Yamanaka Shinya, Nakamura Makoto
Abstract excerpt
Translational regulation has been to shown to play major roles in the patterning of the early Drosophila embryo. The eIF4G family member NAT1/p97/DAP5 has been identified as a novel translational repressor. To genetically dissect the in vivo function of this unconventional eIF4G-related translational regulator, Drosophila NAT1 (dNAT1) mutants were isolated using a reverse-genetics approach. Four transposon...
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