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Article

Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype.

Blood - 15 Sept 1992

Arceci R J, Stieglitz K, Bierer B E

Abstract excerpt

The multidrug-resistant (MDR) phenotype is characterized in vitro by the resistance displayed by cell lines to a broad spectrum of natural product cytotoxic agents. This high level of cross-resistance is due to the increased expression of a membrane glycoprotein termed P-glycoprotein. Encoded in...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Azides
Binding, Competitive
Daunorubicin
Drug Resistance
Drug Synergism
Humans
Iodine Radioisotopes
Membrane Glycoproteins
Phenotype
Polyenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prazosin

Sirolimus

Tacrolimus

Tumor Cells, Cultured

Source

Identifiers

PMID: 1381629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1381629-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype.PMID 1381629Read ↗

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.Semantic proximity Read ↗

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.Semantic proximity Read ↗

Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.Semantic proximity Read ↗

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Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.Semantic proximity Read ↗

Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma.Semantic proximity Read ↗

Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.Semantic proximity Read ↗

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.Semantic proximity Read ↗

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.Semantic proximity Read ↗

Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine.Semantic proximity Read ↗

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.Semantic proximity Read ↗

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