Cdc18p can block mitosis by two independent mechanisms.

doi:10.1242/jcs.111.20.3101

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Article

Cdc18p can block mitosis by two independent mechanisms.

Journal of cell science - 1 Oct 1998

Greenwood E, Nishitani H, Nurse P

Abstract excerpt

The DNA replication checkpoint is required to maintain the integrity of the genome, inhibiting mitosis until S phase has been successfully completed. The checkpoint preventing premature mitosis in Schizosaccharomyces pombe relies on phosphorylation of the tyrosine-15 residue on cdc2p to prevent i...

Topics

Blotting, Western
CDC2 Protein Kinase
Cell Cycle Proteins
Cyclin B
DNA Replication
DNA-Binding Proteins
Fungal Proteins
Genes, Fungal
Mitosis
Mutation
Nuclear Proteins
Protein-Tyrosine Kinases
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Transglutaminases

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