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Article

Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.

Nucleic acids research - 1 Jan 2007

Fersht Naomi, Hermand Damien, Hayles Jacqueline, Nurse Paul

Abstract excerpt

A screen for genes that can ectopically activate a Rad3-dependent checkpoint block over mitosis in fission yeast has identified the DNA replication initiation factor cdc18 (known as CDC6 in other organisms). Either a stabilized form of Cdc18, the Cdc18-T6A phosphorylation mutant, or overexpression of wild type Cdc18, activate the Rad3-dependent S-M checkpoint in the apparent absence of detectable replication...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17690116
DOI: 10.1093/nar/gkm527
PMCID: PMC2018612

Genes

CDC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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