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Article

DNA double-strand breaks and DNA recombination in benzene metabolite-induced genotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2012

Tung Emily W Y, Philbrook Nicola A, Macdonald Katharine D D, Winn Louise M

Abstract excerpt

In utero exposure to environmental carcinogens, including the ubiquitous pollutant benzene, may cause DNA damage in the fetus, leading to an increased risk for the development of childhood cancer. Benzene metabolite-induced DNA double-strand breaks (DSBs) may undergo erroneous repair, leading to chromosomal aberrations including chromosomal inversions and translocations. In this study, fetal murine hematopoietic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 22247006
DOI: 10.1093/toxsci/kfs001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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