Article
The p-benzoquinone DNA adducts derived from benzene are highly mutagenic.
DNA repair - 8 Dec 2005
Xie Zhongwen, Zhang Yangbin, Guliaev Anton B, Shen Huiyun, Hang Bo, Singer B, Wang Zhigang
Abstract excerpt
Benzene is a human leukemia carcinogen, resulting from its cellular metabolism. A major benzene metabolite is p-benzoquinone (pBQ), which can damage DNA by forming the exocyclic base adducts pBQ-dC, pBQ-dA, and pBQ-dG in vitro. To gain insights into the role of pBQ in benzene genotoxicity, we examined in vitro translesion synthesis and in vivo mutagenesis of these pBQ adducts. Purified REV1 and Polkappa were...
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