Article
Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2000
Pollock B G, Ferrell R E, Mulsant B H, Mazumdar S, Miller M, Sweet R A, Davis S, Kirshner M A, Houck P R, Stack J A, Reynolds C F, Kupfer D J
Abstract excerpt
The relationship of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) to antidepressant response was examined in 95 elderly patients receiving a protocolized treatment for depression with paroxetine or nortriptyline. Patients were treated for up to 12 weeks and assessed weekly with clinical ratings and measurements of plasma drug concentrations. Twenty-one of the paroxetine-treated subjects...
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