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Article

Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.

Journal of virology - 1 Nov 2000

Twizere J C, Kerkhofs P, Burny A, Portetelle D, Kettmann R, Willems L

Abstract excerpt

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second function, immortalization of primary cells in vitro. These activities of Tax can be dissociated on the basis of point mutations within specific regions of the protein. For example, mutation of the...

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Identifiers

PMID: 11024116
DOI: 10.1128/jvi.74.21.9895-9902.2000
PMCID: PMC102026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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