Article
L233P mutation of the Tax protein strongly correlated with leukemogenicity of bovine leukemia virus.
Veterinary microbiology - 27 Dec 2013
Inoue Emi, Matsumura Keiko, Soma Norihiko, Hirasawa Shintaro, Wakimoto Mayuko, Arakaki Yoshihiro, Yoshida Takashi, Osawa Yoshiaki, Okazaki Katsunori
Abstract excerpt
The bovine leukemia virus (BLV) Tax protein is believed to play a crucial role in leukemogenesis by the virus. BLV usually causes asymptomatic infections in cattle, but only one-third develop persistent lymphocytosis that rarely progress after a long incubation period to lymphoid tumors, namely enzootic bovine leucosis (EBL). In the present study, we demonstrated that the BLV tax genes could be divided into two...
Topics
- Age Distribution
- Alleles
- Animals
- Cattle
- Enzootic Bovine Leukosis
- Female
- Gene Expression Regulation, Viral
- Gene Products, tax
- Genetic Variation
- Japan
- Leukemia Virus, Bovine
- Mutation
- Phylogeny
- Polymerase Chain Reaction