Article
A mutant form of the tax protein of bovine leukemia virus (BLV), with enhanced transactivation activity, increases expression and propagation of BLV in vitro but not in vivo.
Journal of virology - 1 Feb 2003
Tajima Shigeru, Takahashi Masahiko, Takeshima Shin-Nosuke, Konnai Satoru, Yin Shan Ai, Watarai Shinobu, Tanaka Yoshimasa, Onuma Misao, Okada Kosuke, Aida Yoko
Abstract excerpt
In a previous study, we identified an interesting mutant form of the Tax protein of bovine leukemia virus (BLV), designated D247G. This mutant protein strongly transactivated the long terminal repeat of BLV and was also able to transactivate the cellular proto-oncogene c-fos. This finding suggested that BLV that encode the mutant protein might propagate and induce lymphoma more efficiently than wild-type BLV. To...
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