Article
Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis.
BMC genomics - 28 Mar 2012
Arainga Mariluz, Takeda Eri, Aida Yoko
Abstract excerpt
BACKGROUND: Bovine leukemia virus (BLV) is associated with enzootic bovine leukosis and is closely related to human T-cell leukemia virus type I. The Tax protein of BLV is a transcriptional activator of viral replication and a key contributor to oncogenic potential. We previously identified interesting mutant forms of Tax with elevated (TaxD247G) or reduced (TaxS240P) transactivation effects on BLV replication...
Topics
- Animals
- Apoptosis
- Cattle
- Cell Line
- Cell Proliferation
- Down-Regulation
- Gene Products, tax
- HeLa Cells
- Host-Pathogen Interactions
- Humans
- Immune System