Article
Lack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Virology - 10 Jan 1995
Willems L, Kerkhofs P, Burny A, Mammerickx M, Kettmann R
Abstract excerpt
Genetic variation of the Bovine Leukemia Virus (BLV) appears to be limited in vitro and during the latent phase of the disease. However, cells in tumors often harbor deleted proviruses that are defective for expression. In order to gain insight into the involvement of viral genetic variation during pathogenesis, the BLV LTR and the env proviral sequences were analyzed in tumor tissues. A sheep (M230) was injected...
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