Article
Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy.
Cancer research - 15 Feb 2005
Moulés Vincent, Pomier Carole, Sibon David, Gabet Anne-Sophie, Reichert Michal, Kerkhofs Pierre, Willems Luc, Mortreux Franck, Wattel Eric
Abstract excerpt
Almost all cancers are preceded by a prolonged period of clinical latency during which a combination of cellular events helps move carcinogen-exposed cells towards a malignant phenotype. Hitherto, investigating the fate of premalignant cells in vivo remained strongly hampered by the fact that these cells are usually indistinguishable from their normal counterparts. Here, for the first time, we have designed a...
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