Discrimination between transfer-RNAs by tyrosyl-tRNA synthetase.

doi:10.1016/0300-9084(93)90009-h

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Article

Discrimination between transfer-RNAs by tyrosyl-tRNA synthetase.

Biochimie - 1 Jan 1993

Bedouelle H, Guez-Ivanier V, Nageotte R

Abstract excerpt

We have constructed a model of the complex between tyrosyl-tRNA synthetase (TyrRS) from Bacillus stearothermophilus and tRNA(Tyr) by successive cycles of predictions, mutagenesis of TyrRS and molecular modeling. We confront this model with data obtained independently, compare it to the crystal st...

Topics

Binding Sites
Escherichia coli
Geobacillus stearothermophilus
Models, Molecular
Mutation
RNA, Transfer, Amino Acyl
RNA, Transfer, Tyr
Substrate Specificity
Tyrosine-tRNA Ligase

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