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Article

[Incidence of amantadine-resistant influenza A (genotype Ser-31-Asn) in nursing homes in Niigata, Japan].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases - 1 Aug 2000

Saito R, Masuda H, Oshitani H, Suzuki H, Kawasaki S, Sato H

Abstract excerpt

The antiviral agent amantadine specifically inhibit influenza A virus infection, but the emergence of drug-resistant viruses occur more readily with amantadine treatment. In human influenza viruses, single amino acid changes at 4 sites spanning the transmembrane domain of the M2 protein can confer drug resistance. Amantadine was approved for treatment of Parkinson's disease in 1975, and for the influenza A virus...

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Identifiers

PMID: 11019512
DOI: 10.11150/kansenshogakuzasshi1970.74.646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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