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Article

High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza.

The Journal of infectious diseases - 1 Jul 2003

Shiraishi Kyoko, Mitamura Keiko, Sakai-Tagawa Yuko, Goto Hideo, Sugaya Norio, Kawaoka Yoshihiro

Abstract excerpt

Clinical samples from 15 amantadine-treated children were collected serially-before, during, and/or after treatment-and were studied to determine the actual prevalence, timing, and clinical implications of M2 mutational events. After viral RNA extraction and reverse-transcriptase polymerase chain reaction amplification of the viral RNA encoding the M2 protein, the products were cloned into plasmids, and their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12825171
DOI: 10.1086/375799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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