Article
[Search of amantadine-resistance in influenza A strains isolated in Santiago, Chile, 2001-2002].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia - 1 Jun 2005
Fehlmann Elisa, Le Corre Nicole, Abarca Katia, Godoy Paula, Montecinos Luisa, Veloz Ana, Ferrés Marcela
Abstract excerpt
Amantadine has been used for prevention and treatment of influenza A infection. It blocks the proton through the M2 ion channel. Drug-resistant viruses appear quickly when this therapy is used. Single amino acids changes in the H2 protein can confer resistance, being the most frequent one in position 31. Different methods to detect resistant strains have been described. The objectives were to determine the...
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