Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

doi:10.1056/NEJM199803053381002

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Article

Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

The New England journal of medicine - 5 Mar 1998

Bellamy R, Ruwende C, Corrah T, McAdam K P, Whittle H C, Hill A V

Abstract excerpt

BACKGROUND: Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1)...

Topics

Adult
Carrier Proteins
Case-Control Studies
Cation Transport Proteins
Female
Gambia
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Male
Membrane Proteins
Mutation
Odds Ratio
Polymorphism, Genetic
Tuberculosis, Pulmonary

Source

Open in PubMed

Identifiers

PMID: 9486992
DOI: 10.1056/NEJM199803053381002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9486992-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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