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Article

Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

The New England journal of medicine - 5 Mar 1998

Bellamy R, Ruwende C, Corrah T, McAdam K P, Whittle H C, Hill A V

Abstract excerpt

BACKGROUND: Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in...

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Identifiers

PMID: 9486992
DOI: 10.1056/NEJM199803053381002

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Related research

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Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.PMID 9486992Read ↗

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Allelic association between the NRAMP1 gene and susceptibility to tuberculosis in Guinea-Conakry.Semantic proximity Read ↗

5' dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas.Semantic proximity Read ↗

The natural resistance-associated macrophage protein gene in African Americans with sarcoidosis.Semantic proximity Read ↗

3'UTR polymorphisms in the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans.Semantic proximity Read ↗

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NRAMP1 D543N and INT4 polymorphisms in susceptibility to pulmonary tuberculosis: A meta-analysis.Semantic proximity Read ↗

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