Article
Absence of PTEN repeat tract mutation in endometrial cancers with microsatellite instability.
Gynecologic oncology - 1 Oct 2000
Cohn D E, Basil J B, Venegoni A R, Mutch D G, Rader J S, Herzog T J, Gersell D J, Goodfellow P J
Abstract excerpt
OBJECTIVE: PTEN, a tumor suppressor gene shown to be frequently mutated in endometrial cancers, has been suggested to be a target of microsatellite instability (MSI)-driven mutagenesis. We set out to investigate the relationship between MSI and PTEN mutation in a large series of primary endometrial carcinomas. METHODS: Thirty-nine MSI-positive endometrial cancers were evaluated by single-strand conformational...
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