Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc <i>in vivo</i>

26 Sept 2000

Abstract excerpt

Overexpression of c-Myc in immortalized cells increases cell proliferation, inhibits cell differentiation, and promotes cell transformation. Recent evidence suggests that these effects, however, do not necessarily occur when c-Myc is overexpressed in primary mammalian cells. We sought to determine the immediate effects of transient overexpression of c-Myc in primary cells in vivo by using recombinant adenovirus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to PI3K/AKT/mTOR signaling in cancer
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11005843
DOI: 10.1073/pnas.200372597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc <i>in vivo</i>PMID 11005843Read ↗

c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and DiseaseSemantic proximity Read ↗

Reduced Growth Capacity of Hepatocytes from c-myc and c-myc/TGF-α Transgenic Mice in Primary CultureSemantic proximity Read ↗

Oncogene‐specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis†Semantic proximity Read ↗

c-myc-induced hepatocarcinogenesis in the absence of IGF-I receptor.Semantic proximity Read ↗

c-Myc enhances protein synthesis and cell size during B lymphocyte developmentSemantic proximity Read ↗

Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver.Semantic proximity Read ↗

Adenovirus Overrides Cellular Checkpoints for Protein TranslationSemantic proximity Read ↗

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced TumorigenesisSemantic proximity Read ↗

Conditional deletion of c-myc does not impair liver regeneration.Semantic proximity Read ↗

Neoplastic transformation and tumorigenesis by the human protooncogene MYC.Semantic proximity Read ↗

Characterization of liver epithelial cells transfected with myc and/or ras oncogenes.Semantic proximity Read ↗

Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.