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Article

Adenovirus Overrides Cellular Checkpoints for Protein Translation

2 May 2005

Abstract excerpt

mTOR is a critical regulator of protein translation, and plays an important role in controlling cellular replication. Recent studies indicate that nutrient and growth factor mediated activation of mTOR is deregulated in human cancer, and therefore represents an attractive tumor target. However, activation of mTOR is a complex process that is not yet fully understood. DNA viruses and tumor cells often perturb...

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PMID: 15970698
DOI: 10.4161/cc.4.7.1791

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