Article
Conditional deletion of c-myc does not impair liver regeneration.
Cancer research - 1 Jun 2006
Li Feng, Xiang Yan, Potter James, Dinavahi Ramani, Dang Chi V, Lee Linda A
Abstract excerpt
The oncogene c-myc encodes a transcription factor that has long been considered essential to liver regeneration, the process by which fully differentiated hepatocytes proliferate in an attempt to maintain a normal functional mass in response to hepatic injury. Experimental liver regeneration can be induced upon 70% partial hepatectomy and is accompanied by an increase in c-myc expression accompanying the...
Topics
- Alleles
- Animals
- Gene Deletion
- Genes, myc
- Liver Regeneration
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic